{"id":1665,"date":"2023-05-08T17:21:17","date_gmt":"2023-05-08T09:21:17","guid":{"rendered":"https:\/\/hughesbiotech.rmr.tw\/?p=1665"},"modified":"2023-05-08T17:26:19","modified_gmt":"2023-05-08T09:26:19","slug":"%e3%80%8c%e6%a9%99%e7%9a%ae%e7%b4%a0%e5%8f%af%e6%b4%bb%e5%8c%96%e5%b0%8f%e9%bc%a0%e9%95%b7%e5%a3%bd%e5%9f%ba%e5%9b%a0-%e5%bb%b6%e7%b7%a9%e8%80%81%e5%8c%96%e3%80%8d%e5%b0%88%e5%ae%b6%e6%84%8f%e8%a6%8b","status":"publish","type":"post","link":"https:\/\/tw.hughesbiotech.com\/?p=1665","title":{"rendered":"\u300c\u6a59\u76ae\u7d20\u53ef\u6d3b\u5316\u5c0f\u9f20\u9577\u58fd\u57fa\u56e0 \u5ef6\u7de9\u8001\u5316\u300d\u5c08\u5bb6\u610f\u898b"},"content":{"rendered":"

\u8b70\u984c\u80cc\u666f\uff1a<\/strong><\/p>\n

\u570b\u7acb\u967d\u660e\u4ea4\u901a\u5927\u5b78\u751f\u547d\u79d1\u5b78\u7cfb\u66a8\u57fa\u56e0\u9ad4\u79d1\u5b78\u7814\u7a76\u6240\u8521\u4ead\u82ac\u7279\u8058\u6559\u6388\u3001\u6797\u53e3\u9577\u5e9a\u91ab\u9662\u5916\u79d1\u90e8\u4e3b\u4efb\u8449\u96c6\u5b5d\u3001\u570b\u5bb6\u885b\u751f\u7814\u7a76\u9662\u8207\u885b\u751f\u798f\u5229\u90e8\u570b\u5bb6\u4e2d\u91ab\u85e5\u7814\u7a76\u6240\u7d44\u6210\u7684\u7814\u7a76\u5718\u968a\uff0c\u5728\u53bb\uff082022\uff09\u5e747\u670824\u65e5\u767c\u8868\u65bc\u300a\u751f\u91ab\u79d1\u5b78\u96dc\u8a8c\u300b\uff08Journal of Biomedical Science\uff09\u671f\u520a\u7684\u7814\u7a76\u3008Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice\u3009\uff0c\u5f9e\u5c0f\u9f20\u5be6\u9a57\u4e2d\u767c\u73fe\u300c\u6a59\u76ae\u7d20\u300d\uff08hesperetin\uff09\u53ef\u4fc3\u9032\u300cCisd2\u300d\u57fa\u56e0\u7684\u6d3b\u5316\uff0c\u9054\u5230\u5ef6\u7de9\u8001\u5316\u8207\u5ef6\u9577\u58fd\u547d\u7684\u7814\u7a76\u3002<\/p>\n

\u5c08\u5bb6\u5011\u8868\u793a\uff0c\u8207\u8870\u8001\u6709\u95dc\u7684\u57fa\u56e0\u6709\u5f88\u591a\u7a2e\uff0c\u5728\u6b64\u7814\u7a76\u4e3b\u8981\u662f\u767c\u73fe\u5176\u4e2d\u7684Cisd2\u57fa\u56e0\u53ef\u80fd\u6703\u88ab\u300c\u6a59\u76ae\u7d20\u300d\u6240\u6d3b\u5316\uff0c\u6b64\u7bc7\u662f\u57fa\u790e\u7814\u7a76\u7684\u958b\u7aef\uff0c\u4e26\u53ef\u4f5c\u70ba\u672a\u4f86\u76f8\u95dc\u7814\u7a76\u7684\u767c\u5c55\u65b9\u5411\u3002\u4f46\u8abf\u63a7\u8001\u5316\u7684\u6a5f\u5236\u9084\u6709\u8a31\u591a\u672a\u77e5\uff0c\u5f9e\u751f\u6d3b\u98f2\u98df\u4e2d\u80fd\u651d\u53d6\u5230\u6a59\u76ae\u7d20\u7684\u542b\u91cf\uff0c\u4e5f\u9084\u4e0d\u8db3\u4ee5\u9054\u5230\u5ef6\u7de9\u8001\u5316\u7684\u6548\u679c\u3002\u6b64\u5916\uff0c\u5c0d\u65bc\u4e0d\u662f\u900f\u904eCisd2\u57fa\u56e0\u5f31\u5316\u5f15\u8d77\u7684\u8001\u5316\u6a5f\u5236\uff0c\u6a59\u76ae\u7d20\u662f\u5426\u6709\u6240\u5e6b\u52a9\u4e5f\u503c\u5f97\u6df1\u5165\u63a2\u8a0e\u3002<\/p>\n

\u5f15\u7528\u7814\u7a76\uff1a<\/p>\n

    \n
  1. Yeh, CH., Shen, ZQ., Wang, TW. et al. Hesperetin promotes longevity and delays aging via activation of Cisd2 in naturally aged mice. J Biomed Sci 29, 53 (2022). https:\/\/doi.org\/10.1186\/s12929-022-00838-7<\/a><\/strong><\/li>\n

    \u5c08\u5bb6\u600e\u9ebc\u8aaa\uff1f<\/strong><\/span><\/h3>\n

    2023\u5e7403\u670813\u65e5<\/strong><\/span>
    \n\u570b\u7acb\u81fa\u7063\u5927\u5b78\u8fb2\u696d\u5316\u5b78\u7cfb\u6559\u6388 \u8607\u5357\u7dad<\/strong><\/p>\n

      \n
    1. \u9019\u4efd\u7814\u7a76\u7684\u91cd\u8981\u6027\u70ba\u4f55\uff1f<\/strong><\/li>\n<\/ol>\n

      \u8001\u5316\u662f\u4eba\u751f\u5fc5\u7d93\u4e4b\u8def\uff0c\u8981\u5982\u4f55\u4fdd\u6301\u8eab\u9ad4\u5065\u5eb7\u7684\u8001\u5316\uff0c\u662f\u73fe\u4ee3\u4eba\u8ffd\u6c42\u9577\u58fd\u6ce8\u91cd\u7684\u8ab2\u984c\u4e4b\u4e00\u3002\u967d\u660e\u4ea4\u901a\u5927\u5b78\u8521\u4ead\u82ac\u6559\u6388\u7814\u7a76\u5718\u968a\u65bc2009\u5e74\u767c\u73fe\u4f4d\u65bc\u4eba\u985e\u7b2c\u56db\u865f\u67d3\u8272\u9ad4\u4e2d\u7684\u300cCisd2\u300d\u662f\u9577\u58fd\u57fa\u56e0\uff0c\u53ef\u4ee5\u8abf\u7bc0\u54fa\u4e73\u52d5\u7269\u7684\u58fd\u547d\u3001\u5ef6\u7de9\u8870\u8001\u3002\u53bb\u5e74\u767c\u8868\u7684\u9019\u4efd\u7814\u7a76\u8521\u6559\u6388\u5718\u968a\u9032\u4e00\u6b65\u5f9e\u300c\u795e\u8fb2\u672c\u8349\u7d93\u300d\u8a18\u8f09\u768460\u7a2e\u4e0a\u54c1\u4e2d\u85e5\u6750\u88e1\u7684\u627e\u5230\u53ef\u4ee5\u7279\u5b9a\u6d3b\u5316Cisd2\u57fa\u56e0\u7684\u95dc\u9375\u6210\u5206\u2014\u6a59\u76ae\u7d20\uff08hesperetin\uff09\u3002\u6a59\u76ae\u7d20\u80fd\u4fc3\u9032Cisd2\u9577\u58fd\u57fa\u56e0\u8868\u73fe\u4e26\u5065\u5eb7\u7684\u5ef6\u9577\u58fd\u547d\uff0c\u66f4\u80fd\u6062\u5fa9\u8001\u5316\u7684\u5fc3\u81df\u53ca\u808c\u8089\uff0c\u91cd\u62fe\u5e74\u8f15\u6642\u671f\u7684\u751f\u7406\u6a5f\u80fd\uff0c\u7dad\u6301\u8001\u5e74\u6642\u671f\u7684\u5065\u5eb7\u72c0\u614b\u3002\u9019\u7bc7\u7814\u7a76\u5f9e\u5929\u7136\u7269\u4e2d\u9996\u6b21\u627e\u5230Cisd2\u9776\u5411\u6d3b\u5316\u5291\uff0c\u4e0d\u50c5\u8b49\u5be6\u900f\u904e\u5c0f\u5206\u5b50\u80fd\u6d3b\u5316\u9577\u58fd\u57fa\u56e0\u8868\u73fe\uff0c\u9054\u5230\u6297\u8870\u8001\u4e26\u5065\u5eb7\u9577\u58fd\u7684\u6548\u679c\uff0c\u66f4\u6709\u52a9\u65bc\u672a\u4f86\u958b\u767c\u6a59\u76ae\u7d20\u76f8\u95dc\u7522\u54c1\uff0c\u671f\u8a31\u80fd\u5be6\u73fe\u5ef6\u7de9\u8001\u5316\u8207\u5ef6\u5e74\u76ca\u58fd\u7684\u529f\u6548\u3002<\/p>\n

        \n
      1. \u9084\u6709\u54ea\u4e9b\u5929\u7136\u7269\u5177\u6709\u5ef6\u7de9\u8001\u5316\u53ca\u5ef6\u9577\u58fd\u547d\u7684\u4f5c\u7528\u5462? \u9664\u4e86Cisd2\u57fa\u56e0\u9084\u6709\u5176\u4ed6\u8207\u58fd\u547d\u8abf\u63a7\u76f8\u95dc\u7684\u57fa\u56e0\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

        \u4eba\u985e\u7684\u8001\u5316\u5be6\u969b\u4e0a\u8207\u300c\u81ea\u7531\u57fa\u300d\u606f\u606f\u76f8\u95dc\u3002\u81ea\u7531\u57fa\u662f\u65b0\u9673\u4ee3\u8b1d\u5fc5\u7136\u7522\u751f\u7684\u7522\u7269\uff0c\u5177\u6709\u5f88\u5f37\u7684\u53cd\u61c9\u6027\uff0c\u6703\u9020\u6210\u4eba\u9ad4\u7d30\u80de\u4e2d\u57fa\u56e0\u548c\u86cb\u767d\u8cea\u7684\u300c\u6c27\u5316\u300d\u3002\u7d30\u80de\u5167\u7684\u6d3b\u6027\u7269\u8cea\u4e00\u65e6\u6c27\u5316\uff0c\u5c31\u50cf\u9435\u751f\u93fd\u4e00\u822c\uff0c\u6703\u9010\u6f38\u5931\u53bb\u6b63\u5e38\u529f\u80fd\u3002\u56e0\u6b64\u6297\u8001\u5316\u7684\u95dc\u9375\u5373\u662f\u6297\u6c27\u5316\uff0c\u98f2\u98df\u4e2d\u88dc\u5145\u8db3\u5920\u7684\u6297\u6c27\u5316\u6210\u5206\u4f86\u5e6b\u52a9\u5f15\u5c0e\u8eab\u9ad4\u5167\u7684\u81ea\u7531\u57fa\u6b63\u5e38\u4ee3\u8b1d\u3002\u65b0\u9bae\u852c\u679c\u4e2d\u542b\u6709\u5404\u7a2e\u7dad\u751f\u7d20\u3001\u591a\u915a\u985e\u690d\u5316\u7d20\uff0c\u5be6\u969b\u4e0a\u5c31\u662f\u81ea\u7136\u754c\u8ce6\u4e88\u4eba\u985e\u6700\u4f73\u6297\u6c27\u5316\u7522\u54c1\uff0c\u4f8b\u5982\u7da0\u8336\u4e2d\u300c\u5152\u8336\u7d20\u300d\u3001\u5927\u8c46\u4e2d\u7684\u300c\u7570\u9ec3\u916e\u300d\u3001\u8461\u8404\u4e2d\u7684\u300c\u767d\u85dc\u8606\u9187\u300d\u3001\u829d\u9ebb\u4e2d\u7684\u300c\u829d\u9ebb\u6728\u915a\u7d20\u300d\u7b49\uff0c\u90fd\u662f\u5927\u5bb6\u8033\u719f\u80fd\u8a73\u7684\u6297\u6c27\u5316\u6210\u5206\u3002\u8a31\u591a\u7814\u7a76\u5831\u544a\u6307\u51fa\u9019\u4e9b\u6210\u5206\u80fd\u5920\u8abf\u7bc0\u8870\u8001\u53ca\u9577\u58fd\u57fa\u56e0\uff0c\u9054\u5230\u5ef6\u7de9\u8001\u5316\u4e26\u5ef6\u9577\u58fd\u547d\u7684\u4f5c\u7528\u3002\u7136\u800c\uff0c\u9019\u4e9b\u529f\u6548\u6210\u5206\u5728\u5929\u7136\u98df\u7269\u4e2d\u542b\u91cf\u90fd\u5f88\u4f4e\uff0c\u800c\u4e14\u5927\u591a\u6578\u7684\u591a\u915a\u985e\u690d\u5316\u7d20\u6709\u6c34\u6eb6\u6027\u4e0d\u4f73\u3001\u5438\u6536\u7387\u4f4e\u7684\u554f\u984c\uff0c\u56e0\u6b64\u50c5\u9760\u65e5\u5e38\u98f2\u98df\u7121\u6cd5\u651d\u53d6\u5230\u6709\u6548\u5291\u91cf\uff0c\u901a\u5e38\u96e3\u4ee5\u767c\u63ee\u4f5c\u7528\u3002<\/p>\n

        \u8fd1\u5e74\u4f86\uff0c\u79d1\u5b78\u5bb6\u767c\u73fe\u4e86\u8a31\u591a\u540d\u5b57\u50cf\u662f\u5bc6\u78bc\u822c\u7684\u57fa\u56e0\uff1aBub1b\u3001Cisd2\u3001hMTH1\u3001Klotho\u3001Pawr\u3001Pparg\u3001Pten\u3001Sirt1\u548cSirt6\uff0c\u9019\u4e9b\u57fa\u56e0\u7684\u904e\u5ea6\u8868\u73fe\u548c\u5254\u9664\u6703\u9020\u6210\u5be6\u9a57\u52d5\u7269\u58fd\u547d\u7684\u5ef6\u9577\u548c\u7e2e\u77ed\uff0c\u5176\u4e2d\u50c5\u6709Cisd2\u548chMTH1\u7d93\u7d71\u8a08\u6578\u5b78\u6a21\u578b\u8b49\u5be6\u8207\u5ef6\u7de9\u4eba\u53e3\u8001\u5316\u6709\u95dc\u3002\u672c\u7bc7\u7814\u7a76\u5c07\u7126\u9ede\u96c6\u4e2d\u5728Cisd2\u57fa\u56e0\uff0c\u5728\u5929\u7136\u7269\u4e2d\u627e\u5230\u5b58\u5728\u65bc\u67d1\u6a58\u88e1\u7684\u300c\u6a59\u76ae\u7d20\u300d\uff0c\u5b83\u80fd\u6d3b\u5316\u9577\u58fd\u57fa\u56e0\u80fd\u9054\u5230\u6297\u8870\u8001\u4e26\u5065\u5eb7\u9577\u58fd\u7684\u6548\u679c\uff0c\u76f8\u4fe1\u9019\u500b\u5177\u6709\u6a19\u9776\u8abf\u63a7\u9577\u58fd\u57fa\u56e0\u7684\u5c0f\u5206\u5b50\uff0c\u7d93\u904e\u773e\u79d1\u5b78\u5bb6\u7684\u9032\u4e00\u6b65\u7814\u7a76\uff0c\u5c07\u4f86\u6703\u6210\u70ba\u5065\u5eb7\u8001\u5316\u53ca\u56b4\u9577\u58fd\u547d\u7684\u660e\u65e5\u4e4b\u661f\u3002<\/p>\n

          \n
        1. \u6c11\u773e\u53ef\u4ee5\u5982\u4f55\u7406\u89e3\u9019\u4efd\u7814\u7a76\uff0c\u5403\u67d1\u6a58\u985e\u6c34\u679c\u771f\u7684\u80fd\u7372\u5f97\u300c\u6a59\u76ae\u7d20\u300d\u55ce\uff1f\u6703\u6709\u52a9\u65bc\u5ef6\u7de9\u8001\u5316\u3001\u5ef6\u9577\u58fd\u547d\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

          \u6a59\u76ae\u7d20\uff08Hesperetin\uff09\u9867\u540d\u601d\u7fa9\u65e9\u5148\u5728\u67d1\u6a58\u300c\u76ae\u300d\u7576\u4e2d\u767c\u73fe\uff0c\u7136\u800c\u5728\u679c\u8089\u751a\u81f3\u679c\u76ae\u7576\u4e2d\uff0c\u5e7e\u4e4e\u5168\u662f\u4ee5\u6a59\u76ae\u82f7\uff08Hesperidin\uff09\u7684\u5f62\u5f0f\u5b58\u5728\uff0c\u6a59\u76ae\u82f7\u70ba\u6a59\u76ae\u7d20\u5e36\u4e00\u500b\u96d9\u91a3\uff08Rutinose\uff09\u7684\u5316\u5b78\u7d50\u69cb\uff0c\u4ee5\u4e00\u9846\u67f3\u6a59\u70ba\u4f8b\uff0c\u6a59\u76ae\u82f7\u542b\u91cf\u7d04\u70ba0.75-1.5%\uff0c\u7136\u800c\u7d55\u5927\u90e8\u5206\u7684\u6a59\u76ae\u82f7\u90fd\u5b58\u5728\u65bc\u679c\u76ae\u7576\u4e2d\uff0c\u5e02\u552e\u7684\u67f3\u6a59\u6c41\u5176\u6a59\u76ae\u82f7\u542b\u91cf\u50c5\u7d040.02-0.08%\u3002<\/p>\n

          \u6a59\u76ae\u82f7\u7d93\u53e3\u670d\u651d\u5165\u5f8c\u50c5\u5c11\u90e8\u5206\u6703\u7d93\u8178\u9053\u5fae\u751f\u7269\u4f5c\u7528\u8f49\u63db\u70ba\u6a59\u76ae\u7d20\uff0c\u6a59\u76ae\u7d20\u70ba\u4e0d\u5e36\u6709\u91a3\u57fa\u7684\u7d50\u69cb\u672c\u9ad4 \uff08Aglycone\uff09\uff0c\u4e5f\u662f\u5728\u751f\u7269\u9ad4\u4e2d\u80fd\u5920\u767c\u63ee\u751f\u7406\u529f\u6548\u7684\u6d3b\u6027\u578b\u614b\u3002\u7136\u800c\uff0c\u6a59\u76ae\u82f7\u53c8\u5b58\u5728\u4eba\u9ad4\u751f\u7269\u53ef\u5229\u7528\u7387\uff08Oral bioavailability\uff09\u5dee\u7684\u554f\u984c\uff0c\u53e3\u670d\u5438\u6536\u6bd4\u4f8b\u4e0d\u52309% [1]\uff0c\u5047\u8a2d\u5982\u7814\u7a76\u4e2d\u6709\u6548\u5291\u91cf\u4e00\u5929491 \u6beb\u514b\/\u5929\u7684\u6a59\u76ae\u7d20\u4f86\u4f30\u7b97\uff0c\u4e00\u4f4d60 \u516c\u65a4\u7684\u6210\u4eba\u6bcf\u5929\u81f3\u5c11\u8981\u559d5.5 \u516c\u5347\u7684\u6a59\u6c41\u621621\u9846\u679c\u8089\uff0c\u4e14\u96a8\u67d1\u6a58\u54c1\u7a2e\u4e0d\u540c\u751a\u81f3\u63a8\u4f30\u9700\u559d\u8d85\u904e10\u516c\u5347\u679c\u6c41\u6216\u5403\u5230\u4e0a\u767e\u9846\u67f3\u6a59\u90fd\u6709\u53ef\u80fd\u3002\u6545\u82e5\u55ae\u9760\u65e5\u5e38\u98f2\u98df\uff0c\u5f88\u96e3\u5403\u5230\u6587\u737b\u63d0\u53ca\u7684\u6709\u6548\u5291\u91cf\uff0c\u53cd\u800c\u5148\u651d\u53d6\u904e\u591a\u7684\u6c34\u679c\u7cd6\u5206\u53ca\u71b1\u91cf\uff0c\u9020\u6210\u5065\u5eb7\u8ca0\u64d4\u3002\u4e26\u4e14\uff0c\u53c8\u56e0\u6a59\u76ae\u82f7\u4eba\u9ad4\u53e3\u670d\u751f\u7269\u53ef\u5229\u7528\u7387\u7684\u9650\u5236\uff0c\u9051\u8ad6\u9054\u5230\u6a59\u76ae\u7d20\u5177\u5099\u751f\u7406\u6d3b\u6027\u3001\u767c\u63ee\u529f\u6548\u7684\u5291\u91cf\u3002<\/p>\n

          \u96d6\u7136\u6a59\u76ae\u7d20\u5728\u8a31\u591a\u6587\u737b\u7684\u751f\u7406\u6d3b\u6027\u6548\u679c\u512a\u7570\uff0c\u4f46\u662f\u7531\u65bc\u96e3\u6eb6\u65bc\u6c34\u7684\u7279\u6027\uff0c\u5728\u4eba\u9ad4\u5167\u7684\u5438\u6536\u6548\u7387\u4e0d\u4f73\uff0c\u5be6\u969b\u53e3\u670d\u4f7f\u7528\u96e3\u4ee5\u767c\u63ee\u529f\u6548\uff0c\u53ef\u8aaa\u662f\u6a59\u76ae\u7d20\u6700\u5927\u7684\u5f31\u9ede\u3002\u70ba\u4e86\u89e3\u6c7a\u9019\u500b\u554f\u984c\uff0c\u6211\u5011\u5be6\u9a57\u5ba4\u958b\u767c\u4e86\u300c\u78f7\u9178\u916f\u5316\u6a59\u76ae\u7d20\u300d\u3002\u904b\u7528\u7368\u7279\u7684\u5f8c\u751f\u5143\u767c\u9175\u6280\u8853\uff0c\u5229\u7528\u751f\u7269\u8f49\u5316\u6210\u529f\u5730\u5c07\u6a59\u76ae\u82f7\u8207\u78f7\u9178\u6839\u7d50\u5408\uff0c\u4f7f\u6a59\u76ae\u7d20\u7684\u6c34\u6eb6\u6027\u63d0\u9ad8\u5230\u539f\u672c\u768410\u842c\u500d\u4ee5\u4e0a\uff0c\u4e26\u85c9\u7531\u78f7\u9178\u916f\u524d\u9a45\u85e5\u7269\uff08phosphate prodrug\uff09\u6982\u5ff5\uff0c\u5927\u5e45\u63d0\u5347\u4e86\u6a59\u76ae\u7d20\u5728\u9ad4\u5167\u7684\u5438\u6536\u6548\u7387\u9ad8\u9054608%\uff0c\u4f7f\u5176\u767c\u63ee\u66f4\u597d\u7684\u751f\u7406\u6d3b\u6027\u3002\u671f\u8a31\u300c\u78f7\u9178\u916f\u5316\u6a59\u76ae\u7d20\u300d\u9019\u6a23\u7684\u65b0\u7d20\u6750\u672a\u4f86\u80fd\u958b\u767c\u6210\u85e5\u7528\u53ca\u71df\u990a\u529f\u80fd\u6027\u98df\u54c1\uff0c\u61c9\u7528\u65bc\u5ef6\u9577\u5065\u5eb7\u58fd\u547d\u53ca\u6cbb\u7642\u8001\u5e74\u76f8\u95dc\u75be\u75c5\uff0c\u53ef\u5c07\u6b64\u4efd\u7814\u7a76\u7684\u6982\u5ff5\u5ef6\u4f38\u4e26\u9032\u4e00\u6b65\u63d0\u5347\u5176\u6709\u6548\u6027\u3002<\/p>\n

          2023\u5e7403\u670814\u65e5<\/strong><\/span>
          \n\u5f70\u5316\u57fa\u7763\u6559\u91ab\u9662\u7c92\u7dda\u9ad4\u91ab\u5b78\u66a8\u81ea\u7531\u57fa\u7814\u7a76\u9662\u9662\u9577 \u9b4f\u8000\u63ee<\/strong><\/p>\n

            \n
          1. \u9019\u4efd\u7814\u7a76\u7684\u91cd\u8981\u6027\u70ba\u4f55\uff1f<\/strong><\/li>\n<\/ol>\n

            \u5728\u9019\u4e00\u4efd\u7814\u7a76\u4e2d\uff0c\u4f5c\u8005\u4f7f\u7528Cisd2\u57fa\u56e0\uff08\u4f4d\u65bc\u7b2c\u56db\u865f\u67d3\u8272\u9ad44q22-24\u7684\u5340\u57df\uff09\u5254\u9664\u5c0f\u9f20\u548c\u81ea\u7136\u8001\u5316\u7684\u5c0f\u9f20\u4f86\u9935\u98df\u6a59\u76ae\u7d20\uff0c\u7d50\u679c\u986f\u793a\uff1a\u5728\u4f7f\u7528\u7684\u5291\u91cf\u4e0b\uff0c\u6a59\u76ae\u7d20\u53ef\u4ee5\u900f\u904e\u589e\u52a0\u7c92\u7dda\u9ad4\u529f\u80fd\u548c\u9223\u96e2\u5b50\u8abf\u7bc0\u800c\u6539\u5584\u8001\u5316\u7684\u6307\u6a19\uff0c\u6e1b\u5c11\u8001\u5316\u76f8\u95dc\u75be\u75c5\u7684\u767c\u751f\u3002\u5148\u524d\u7684\u5c0f\u9f20\u6d3b\u9ad4\u7814\u7a76\u548c\u6d3b\u9ad4\u5916\u7d30\u80de\u7814\u7a76\u5df2\u7d93\u8b49\u5be6\uff0cCisd2\u57fa\u56e0\u8868\u9054\u70bamRNA\u548c\u86cb\u767d\u8cea\u96a8\u5e74\u9f61\u589e\u52a0\u800c\u964d\u4f4e\uff0c\u4e14Cisd2\u57fa\u56e0\u5254\u9664\u6703\u52a0\u901f\u5c0f\u9f20\u8001\u5316\u3001Cisd2\u57fa\u56e0\u9ad8\u8868\u9054\u4e4b\u8f49\u6b96\u5c0f\u9f20\u53ef\u7a0d\u5fae\u5ef6\u9577\u58fd\u547d\u3002\u56e0\u6b64\uff0c\u6b64\u7814\u7a76\u7684\u91cd\u8981\u6027\u662f\u9996\u5ea6\u8b49\u660e\u6a59\u76ae\u7d20\u9019\u500b\u6c92\u6709\u52d5\u7269\u6bd2\u6027\u7684\u5c0f\u5206\u5b50\u53ef\u4ee5\u6d3b\u5316Cisd2\u57fa\u56e0\u800c\u5ef6\u9577\u8001\u9081\u5c0f\u9f20\u7684\u58fd\u547d\uff0c\u9935\u98df\u6a59\u76ae\u7d20\u7684\u5c0f\u9f20\u808c\u8089\u7d44\u7e54\u4e2d\u8868\u9054\u6709\u8b8a\u5316\u7684\u57fa\u56e079%\u8207Cisd2\u4e0b\u6e38\u8abf\u63a7\u6709\u76f8\u95dc\u6027\uff0c\u4e3b\u8981\u662f\u53c3\u8207\u65b0\u9673\u4ee3\u8b1d\uff0873.6%\uff09\u548c\u7c92\u7dda\u9ad4\u529f\u80fd\uff0818.1%\uff09\u3002\u6a59\u76ae\u7d20\u5c0d\u65bc\u7d30\u80de\u8f49\u9304\u9ad4\uff08transcriptome\uff09\u7684\u5f71\u97ff\u4ee5\u65b0\u9673\u4ee3\u8b1d\u3001\u86cb\u767d\u8cea\u964d\u89e3\u8f49\u63db\u4e4b\u52d5\u614b\u5e73\u8861\u3001\u7c92\u7dda\u9ad4\u529f\u80fd\u8207\u6c27\u5316\u58d3\u8feb\u3001\u7d30\u80de\u6b7b\u4ea1\u8207\u8001\u5316\uff0c\u4ee5\u53ca\u514d\u75ab\u548c\u767c\u708e\u53cd\u61c9\u7b495\u5927\u9014\u5f91\u6700\u70ba\u986f\u8457\uff0c\u5176\u5206\u5b50\u5c64\u6b21\u7684\u4f5c\u7528\u5728\u5fc3\u808c\u548c\u9aa8\u9abc\u808c\u7d44\u7e54\u975e\u5e38\u76f8\u4f3c\uff0c\u6a59\u76ae\u7d20\u53ef\u6709\u6548\u6e1b\u7de9\u56e0\u8001\u5316\u800c\u8870\u9000\u7684\u65b0\u9673\u4ee3\u8b1d\u529f\u80fd\uff0c\u4e26\u4e14\u6e1b\u5c11\u6c27\u81ea\u7531\u57fa\uff08reactive oxygen species\uff09\u548c\u6c2e\u81ea\u7531\u57fa\uff08reactive nitrogen species\uff09\u7684\u7522\u751f\u3002\u82e5\u80fd\u627e\u5230\u5176\u5b83\u7684Cisd2\u6d3b\u5316\u5291\u800c\u4e14\u8b49\u660e\u4e5f\u80fd\u589e\u5f37\u7c92\u7dda\u9ad4\u529f\u80fd\u548c\u7d30\u80de\u5167\u9223\u96e2\u5b50\u6046\u5b9a\u4e26\u986f\u8457\u5730\u5ef6\u9577\u5c0f\u9f20\u58fd\u547d\uff0c\u5247\u9019\u4e00\u7bc7\u8ad6\u6587\u7684\u63a8\u8ad6\u5c07\u66f4\u6709\u8aaa\u670d\u529b\uff01<\/p>\n

              \n
            1. \u9019\u4efd\u7814\u7a76\u6709\u54ea\u4e9b\u63a8\u8ad6\u7684\u9650\u5236\uff1f\u53e3\u670d\u300c\u6a59\u76ae\u7d20\u300d\u8207\u6d3b\u5316Cisd2\u57fa\u56e0\u7684\u95dc\u806f\u6027\uff1f\u9664\u4e86Cisd2\u57fa\u56e0\u8207\u8001\u5316\u6709\u95dc\u4ee5\u5916\uff0c\u9084\u6709\u5176\u4ed6\u8207\u8001\u5316\u8abf\u63a7\u76f8\u95dc\u7684\u57fa\u56e0\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

              \u672c\u7814\u7a76\u6709\u5e7e\u500b\u9650\u5236\uff0c\u9996\u5148\u662fCisd2\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\uff08heterozygous knockout mice\uff09\u4e0d\u662f\u81ea\u7136\u8001\u5316\u7684\u52d5\u7269\u6a21\u5f0f\uff0c\u6a59\u76ae\u7d20\u5c0dCisd2\u57fa\u56e0\u5254\u9664\u5c0f\u9f20\u548c\u81ea\u7136\u8001\u5316\u5c0f\u9f20\u7684\u4f5c\u7528\u4e0d\u80fd\u76f8\u63d0\u4e26\u8ad6\uff08\u4f5c\u7528\u6a5f\u8f49\u61c9\u8a72\u4e0d\u540c\uff09\u3002\u800c\u4e14\uff0c\u5728\u5c0f\u9f20\u5fc3\u808c\u548c\u9aa8\u9abc\u808c\u6240\u89c0\u5bdf\u5230\u7684\u6a59\u76ae\u7d20\u7684\u9019\u4e9b\u4fdd\u8b77\u4f5c\u7528\u61c9\u8a72\u5728\u9748\u9577\u985e\u52d5\u7269\uff08\u7334\u5b50\u6216\u7329\u7329\uff09\u9032\u4e00\u6b65\u9a57\u8b49\u3002\u518d\u8005\uff0c\u672c\u7814\u7a76\u4e26\u672a\u63a2\u8a0e\u6a59\u76ae\u7d20\u6d3b\u5316Cisd2\u7684\u6a5f\u5236\uff0c\u672a\u80fd\u89e3\u91cb\u6a59\u76ae\u7d20\u662f\u900f\u904e\u57fa\u56e0\u7684\u8f49\u9304\u6216\u8f49\u8b6f\u6d3b\u6027\u589e\u5f37\u6216\u900f\u904eCisd2\u589e\u52a0\u800c\u6709\u6548\u8abf\u7bc0\u7d30\u80de\u5167\u9223\u96e2\u5b50\u6fc3\u5ea6\u800c\u4fc3\u9032\u5c0f\u9f20\u7684\u5065\u5eb7\u4ee5\u81f4\u5ef6\u9577\u58fd\u547d\u3002\u6700\u5f8c\uff0c\u672c\u7814\u7a76\u4e26\u672a\u8aaa\u660e\u98df\u7528\u6a59\u76ae\u7d20\u7684\u5c0f\u9f20\u5176\u9ad4\u5167\u7d44\u7e54\u7d30\u80de\u4e2d\u7684\u6a59\u76ae\u7d20\u662f\u5426\u53ef\u76f4\u63a5\u767c\u751f\u6d3b\u5316Cisd2\u7684\u4f5c\u7528\uff0c\u6216\u9700\u8981\u5728\u52d5\u7269\u9ad4\u5167\u4ee3\u8b1d\u70ba\u5176\u5b83\u66f4\u5177\u6709\u751f\u7269\u6d3b\u6027\u7684\u6b21\u7d1a\u4ee3\u8b1d\u7269\u3002<\/p>\n

                \n
              1. \u6c11\u773e\u53ef\u4ee5\u5982\u4f55\u7406\u89e3\u9019\u4efd\u7814\u7a76\uff0c\u5403\u67d1\u6a58\u985e\u6c34\u679c\u771f\u7684\u80fd\u7372\u5f97\u300c\u6a59\u76ae\u7d20\u300d\u55ce\uff1f\u6703\u6709\u52a9\u65bc\u5ef6\u7de9\u8001\u5316\u3001\u5ef6\u9577\u58fd\u547d\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

                \u4e00\u822c\u6c11\u773e\u82e5\u60f3\u900f\u904e\u98df\u7528\u542b\u6709\u6a59\u76ae\u7d20\u7684\u67da\u5b50\u6216\u67f3\u6a59\u7b49\u6c34\u679c\u4f86\u5ef6\u9577\u58fd\u547d\u53ef\u80fd\u6709\u56f0\u96e3\uff0c\u56e0\u70ba\u5f9e\u98df\u7269\u548c\u6c34\u679c\u4e2d\u6240\u651d\u53d6\u7684\u6a59\u76ae\u7d20\u7684\u91cf\u4e0d\u8db3\u4ee5\u5728\u7d30\u80de\u5167\uff08\u751a\u81f3\u8981\u9032\u5165\u7d30\u80de\u6838\u5167\uff09\u9054\u5230\u6709\u6548\u6d3b\u5316Cisd2\u57fa\u56e0\u7684\u6fc3\u5ea6\uff0c\u53ef\u80fd\u9700\u8981\u6bcf\u5929\u98df\u7528\u4e00\u5b9a\u9ad4\u7a4d\u7684\u6fc3\u7e2e\u6db2\u6216\u4e7e\u71e5\u7c89\u672b\u72c0\u614b\u7684\u6a59\u76ae\u7d20\uff08\uff1e491 \u6beb\u514b\/60 \u516c\u65a4\/\u5929\uff09\uff0c\u4e26\u5206\u6790\u9032\u5165\u4eba\u9ad4\u5404\u7d44\u7e54\u7d30\u80de\u7684\u6a59\u76ae\u7d20\u6fc3\u5ea6\uff0c\u64da\u4ee5\u8a55\u4f30\u662f\u5426\u53ef\u9054\u5230\u6709\u6548\u4f5c\u7528\u7684\u5291\u91cf\uff0c\u9019\u4e9b\u5be6\u9a57\u7684\u7d50\u679c\u5c07\u53ef\u6c7a\u5b9a\u958b\u767c\u6a59\u76ae\u7d20\u70ba\u5ef6\u7de9\u8001\u5316\u6216\u5ef6\u9577\u58fd\u547d\u7684\u529f\u80fd\u6027\u98df\u54c1\u6216\u85e5\u54c1\u662f\u5426\u6709\u53ef\u884c\u6027\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u5728\u5c0f\u9f20\u5be6\u9a57\u6240\u89c0\u5bdf\u5230\u7684\u6a59\u76ae\u7d20\u5ef6\u9577\u58fd\u547d\u53ca\u5065\u5eb7\u58fd\u547d\u7684\u4f5c\u7528\u4e0d\u4e00\u5b9a\u53ef\u4ee5\u61c9\u7528\u65bc\u4eba\u985e\uff0c\u9019\u597d\u6bd4\u4e00\u4e9b\u5728\u52d5\u7269\u8a66\u9a57\u6709\u6548\u7684\u65b0\u7a4e\u85e5\u7269\u5230\u4e86\u81e8\u5e8a\u8a66\u9a57\u5c31\u5931\u6557\u4e86\u3002<\/p>\n

                2023\u5e7403\u670819\u65e5<\/strong><\/span>
                \n\u81fa\u5317\u91ab\u5b78\u5927\u5b78\u8f49\u8b6f\u91ab\u5b78\u535a\u58eb\u5b78\u4f4d\u5b78\u7a0b\u526f\u6559\u6388 \u9673\u6021\u5e06<\/strong><\/p>\n

                  \n
                1. \u9019\u4efd\u7814\u7a76\u7684\u91cd\u8981\u6027\u70ba\u4f55\uff1f<\/strong><\/li>\n<\/ol>\n

                  \u5728\u300c\u5c11\u5b50\u5316\u300d\u7684\u8da8\u52e2\u63a8\u6ce2\u81f3\u4eca\uff0c\u793e\u6703\u4eba\u53e3\u8001\u5e74\u6bd4\u4f8b\u9010\u6f38\u4e0a\u5347\uff0c\u8001\u5e74\u91ab\u5b78\u7814\u7a76\u4ee5\u53ca\u9ad8\u9f61\u5065\u5eb7\u7167\u8b77\u6210\u70ba\u73fe\u4eca\u9700\u8981\u7a4d\u6975\u9032\u884c\u7684\u8ab2\u984c\u3002\u967d\u660e\u4ea4\u901a\u5927\u5b78\u8521\u4ead\u82ac\u7279\u8058\u6559\u6388\u7684\u7814\u7a76\u5718\u968a\u5728\u4ee5\u5f80\u7684\u7814\u7a76\u767c\u73feCisd2\u9019\u500b\u57fa\u56e0\u7684\u8868\u73fe\u91cf\u591a\u5be1\uff0c\u6703\u5f71\u97ff\u7684\u500b\u9ad4\u7684\u5065\u5eb7\u8207\u58fd\u547d\u3002\u56e0\u6b64\uff0c\u8521\u6559\u6388\u5718\u968a\u904b\u7528\u4e0d\u540c\u7684\u5c0f\u9f20\u6a21\u5f0f\u4f86\u9032\u884c\u7814\u7a76\uff0c\u5728\u795e\u8fb2\u672c\u8349\u7d93\u4e2d\u773e\u591a\u7684\u85e5\u6750\u8403\u53d6\u7269\u7be9\u9078\u5c0b\u627e\u80fd\u6709\u6548\u6d3b\u5316Cisd2\u8868\u73fe\u7684\u7269\u8cea\uff0c\u5728\u76f8\u4f3c\u7684\u9ec3\u916e\u985e\u5316\u5408\u7269\u4e2d\u627e\u5230\u4e86\u300c\u6a59\u76ae\u7d20\u300d\uff0c\u5176\u53ef\u6297\u6c27\u5316\u4f86\u964d\u4f4e\u9ad4\u5167\u81ea\u7531\u57fa\u7684\u542b\u91cf\uff1b\u5148\u524d\u7814\u7a76\u9084\u6307\u51fa\uff0c\u300c\u6a59\u76ae\u7d20\u300d\u53ef\u964d\u4f4e\u8840\u58d3\u53ca\u81bd\u56fa\u9187\uff0c\u4e26\u4e14\u300c\u6a59\u76ae\u7d20\u300d\u8207\u7dad\u751f\u7d20P\u53ef\u5354\u540c\u4fdd\u8b77\u5fc3\u8840\u7ba1\u529f\u80fd\u3002\u9019\u7bc7\u7814\u7a76\u6307\u51fa\uff0c\u300c\u6a59\u76ae\u7d20\u300d\u53ef\u85c9\u7531\u6d3b\u5316Cisd2\u4f86\u6e1b\u7de9\u8001\u5316\u548c\u5ef6\u9577\u58fd\u547d\u3002\u6e1b\u7de9\u8001\u5316\u5c24\u5176\u91cd\u8981\uff0c\u8001\u5e74\u4eba\u591a\u70ba\u6162\u6027\u75be\u75c5\u6240\u82e6\uff0c\u5728\u8001\u5e74\u751f\u6d3b\u4e2d\uff0c\u82e5\u80fd\u6e1b\u7de9\u8eab\u9ad4\u7d44\u7e54\u5668\u5b98\u7684\u8001\u5316\u548c\u75c5\u8b8a\uff0c\u5728\u5ef6\u9577\u58fd\u547d\u6642\uff0c\u4fdd\u6301\u5065\u5eb7\u800c\u4e26\u975e\u53ea\u6709\u5ef6\u9577\u6642\u9593\uff0c\u5373\u53ef\u6e1b\u8f15\u500b\u4eba\u8207\u5bb6\u5ead\u8ca0\u64d4\u3002\u56e0\u6b64\uff0c\u9019\u6a23\u7684\u7814\u7a76\u6210\u679c\u6709\u6a5f\u6703\u63d0\u4f9b\u627e\u5230\u66f4\u591a\u6709\u52a9\u65bc\u6e1b\u7de9\u8001\u5316\u7684\u85e5\u7269\u3002<\/p>\n

                    \n
                  1. \u9019\u4efd\u7814\u7a76\u6709\u54ea\u4e9b\u63a8\u8ad6\u7684\u9650\u5236\uff1f\u53e3\u670d\u300c\u6a59\u76ae\u7d20\u300d\u8207\u6d3b\u5316Cisd2\u57fa\u56e0\u7684\u95dc\u806f\u6027\uff1f\u9664\u4e86Cisd2\u57fa\u56e0\u8207\u8001\u5316\u6709\u95dc\u4ee5\u5916\uff0c\u9084\u6709\u5176\u4ed6\u8207\u8001\u5316\u8abf\u63a7\u76f8\u95dc\u7684\u57fa\u56e0\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

                    \u751f\u7269\u9ad4\u662f\u76f8\u7576\u8907\u96dc\u7684\uff0c\u55ae\u4e00\u95dc\u9375\u57fa\u56e0\u7684\u8868\u73fe\u8abf\u63a7\u56fa\u7136\u5f88\u91cd\u8981\uff0c\u8981\u7dad\u6301\u5168\u8eab\u751f\u7406\u6a5f\u80fd\u662f\u7531\u4e00\u9023\u4e32\u7684\u57fa\u56e0\u8abf\u63a7\u5b8c\u6210\u7684\u3002Cisd2\u6d3b\u5316\u5f8c\u7684\u4f5c\u7528\u6a5f\u5236\u70ba\u4f55\uff0c\u4ee5\u53ca\u662f\u5426\u5728\u4e0d\u540c\u5668\u5b98\u7d44\u7e54\u4e2d\uff0cCisd2\u7684\u529f\u80fd\u4e5f\u4e0d\u9032\u76f8\u540c\uff0c\u90fd\u662f\u53ef\u4ee5\u7e7c\u7e8c\u6df1\u5165\u63a2\u8a0e\u7684\u3002\u53e6\u5916\uff0c\u7814\u7a76\u4e2d\u6307\u51fa\u300c\u6a59\u76ae\u7d20\u300d\u4e3b\u8981\u662f\u85c9\u7531\u6d3b\u5316Cisd2\u4f86\u9054\u5230\u6297\u8001\u5316\u7684\u529f\u6548\uff0c\u4f46\u300c\u6a59\u76ae\u7d20\u300d\u9084\u662f\u6709\u53ef\u80fd\u85c9\u7531\u6d3b\u5316\u8207Cisd2\u76f8\u985e\u4f3c\u7684\u57fa\u56e0\uff0c\u4f86\u9054\u5230\u529f\u6548\u3002\u66f4\u8b93\u4eba\u60f3\u4e86\u89e3\u7684\u662f\uff0c\u300c\u6a59\u76ae\u7d20\u300d\u7d93\u904e\u6d88\u5316\u9053\u5f8c\u7684\u4ee3\u8b1d\u7269\u662f\u5982\u4f55\u9032\u5165\u6240\u6709\u7d30\u80de\u4e2d\u6d3b\u5316Cisd2\u7684\u5462? \u82e5\u80fd\u66f4\u6e05\u695a\u7684\u7814\u7a76\uff0c\u6216\u8a31\u80fd\u5c0d\u5ef6\u7de9\u8001\u5316\u6709\u66f4\u9032\u4e00\u6b65\u7684\u8a8d\u8b58\u3002<\/p>\n

                    \u81f3\u4eca\u7684\u7814\u7a76\u4e2d\u767c\u73fe\uff0c\u8001\u5316\u7684\u904e\u7a0b\u662f\u7d2f\u7a4d\u6709\u5bb3\u7269\u8cea\u4ee5\u53ca\u6162\u6027\u767c\u708e\u53cd\u61c9\u52a0\u7e3d\u800c\u6210\u3002\u6240\u4ee5\u90e8\u5206\u79d1\u5b78\u5bb6\u6703\u81f4\u529b\u65bc\u7814\u7a76\u65bc\u5982\u4f55\u964d\u4f4e\u9ad4\u5167\u81ea\u7531\u57fa\u7684\u5806\u7a4d\uff0c\u4e5f\u6709\u7814\u7a76\u5982\u4f55\u964d\u4f4e\u767c\u708e\u73fe\u8c61\u3002\u800c\u8207\u9019\u4e9b\u8abf\u7bc0\u76f8\u95dc\u7684\u57fa\u56e0\u90fd\u6709\u53ef\u80fd\u8207\u8001\u5316\u8abf\u63a7\u76f8\u95dc\u3002<\/p>\n

                      \n
                    1. \u6c11\u773e\u53ef\u4ee5\u5982\u4f55\u7406\u89e3\u9019\u4efd\u7814\u7a76\uff0c\u5403\u67d1\u6a58\u985e\u6c34\u679c\u771f\u7684\u80fd\u7372\u5f97\u300c\u6a59\u76ae\u7d20\u300d\u55ce\uff1f\u6703\u6709\u52a9\u65bc\u5ef6\u7de9\u8001\u5316\u3001\u5ef6\u9577\u58fd\u547d\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

                      \u6a59\u76ae\u7d20\u662f\u67d1\u6a58\u985e\u679c\u76ae\u53ca\u5176\u4e0b\u7684\u767d\u8272\u5c64\u4e2d\u8403\u53d6\u800c\u5f97\uff0c\u5e73\u6642\u98df\u7528\u6642\u679c\u76ae\u6703\u88ab\u53bb\u6389\uff0c\u4e0d\u5bb9\u6613\u7372\u53d6\u6a59\u76ae\u7d20\u3002\u5728\u7814\u7a76\u4e2d\u80fd\u5177\u6709\u6297\u8001\u5316\u529f\u6548\u7684\u6a59\u76ae\u7d20\u662f\u7cbe\u7cb9\u51fa\u4f86\u7684\u6fc3\u7e2e\u7269\uff0c\u56e0\u6b64\u76f4\u63a5\u98df\u7528\u67d1\u6a58\u985e\u679c\u76ae\u80fd\u98df\u7528\u4e26\u53d6\u5f97\u7684\u542b\u91cf\u662f\u76f8\u7576\u4f4e\u7684\u3002\u76ee\u524d\u5df2\u77e5\uff0c\u6a59\u76ae\u7d20\u53ef\u4ee5\u6709\u6548\u6297\u6c27\u5316\u4f86\u964d\u4f4e\u81ea\u7531\u57fa\u7d2f\u7a4d\uff0c\u4e26\u4e14\u964d\u4f4e\u81bd\u56fa\u9187\u542b\u91cf\u3002\u56e0\u6b64\u5f97\u77e5\uff0c\u6a59\u76ae\u7d20\u53ef\u85c9\u7531\u63d0\u5347\u7c92\u7dda\u9ad4\u529f\u80fd\u4ee5\u53ca\u8abf\u7bc0\u8eab\u9ad4\u4ee3\u8b1d\u529f\u80fd\u4f86\u7dad\u6301\u5065\u5eb7\uff0c\u9032\u800c\u6709\u6a5f\u6703\u6e1b\u7de9\u8001\u5316\u3001\u5ef6\u9577\u58fd\u547d\u3002\u4f46\u7562\u7adf\u4eba\u985e\u7684\u57fa\u56e0\u8abf\u63a7\u9084\u662f\u8207\u5c0f\u9f20\u53ef\u80fd\u6709\u6240\u4e0d\u540c\uff0c\u9084\u662f\u9700\u8981\u6709\u81e8\u5e8a\u4e0a\u7684\u7814\u7a76\u6578\u64da\u624d\u80fd\u78ba\u8a8d\uff0c\u6a59\u76ae\u7d20\u662f\u5426\u771f\u7684\u80fd\u5e6b\u52a9\u4eba\u985e\u6e1b\u7de9\u8001\u5316\u3001\u5ef6\u9577\u58fd\u547d\u3002<\/p>\n

                      2023\u5e7403\u670825\u65e5<\/strong><\/span>
                      \n\u4e2d\u570b\u91ab\u85e5\u5927\u5b78\u751f\u7269\u91ab\u5b78\u7814\u7a76\u6240\u52a9\u7406\u6559\u6388 \u738b\u5fd7\u8c6a<\/strong><\/p>\n

                        \n
                      1. \u9019\u4efd\u7814\u7a76\u7684\u91cd\u8981\u6027\u70ba\u4f55\uff1f<\/strong><\/li>\n<\/ol>\n

                        \u8521\u6559\u6388\u5718\u968a\u904e\u53bb\u5df2\u8b49\u5be6Cisd2\u57fa\u56e0\u5728\u8001\u5316\u904e\u7a0b\u7684\u91cd\u8981\u6027\u3002\u6b64\u7814\u7a76\u5229\u7528\u7d30\u80de\u8207\u52d5\u7269\u6a21\u5f0f\u7be9\u9078\u5e73\u53f0\uff0c\u5728\u773e\u591a\u7684\u690d\u7269\u8403\u53d6\u5316\u5408\u7269\u4e2d\u767c\u73fe\u6a59\u76ae\u7d20\u53ef\u6709\u6548\u589e\u52a0Cisd2\u7684\u57fa\u56e0\u8868\u73fe\u3002\u5728\u81ea\u7136\u8001\u5316\u7684\u5c0f\u9f20\u52d5\u7269\u6a21\u578b\u4e0a\uff0c\u900f\u904e\u53e3\u670d\u6a59\u76ae\u7d20\u6d3b\u5316Cisd2\u57fa\u56e0\uff0c\u53ef\u9006\u8f49\u8001\u5316\u76f8\u95dc\u57fa\u56e0\uff0c\u8207\u7de9\u89e3\u8001\u5316\u76f8\u95dc\u75c5\u5fb5\u3002<\/p>\n

                        \u9019\u9805\u7814\u7a76\u7684\u91cd\u8981\u6027\u5728\u65bc\u63d0\u4f9b\u4e86\u95dc\u65bc\u5929\u7136\u5316\u5408\u7269\uff1a\u6a59\u76ae\u7d20\u53ef\u900f\u904e\u8abf\u63a7Cisd2\u57fa\u56e0\uff0c\u9032\u800c\u5ef6\u7de9\u8001\u5316\u548c\u4fc3\u9032\u5065\u5eb7\u58fd\u547d\u4e0a\u7684\u65b0\u898b\u89e3\uff0c\u70ba\u958b\u767c\u6297\u8870\u8001\u7642\u6cd5\u548c\u5e72\u9810\u624b\u6bb5\uff0c\u6539\u5584\u5065\u5eb7\u4e26\u5ef6\u9577\u4eba\u985e\u58fd\u547d\u63d0\u4f9b\u4e86\u53ef\u80fd\u7684\u65b0\u601d\u8def\u548c\u4f9d\u64da\u3002<\/p>\n

                          \n
                        1. \u9019\u4efd\u7814\u7a76\u6709\u54ea\u4e9b\u63a8\u8ad6\u7684\u9650\u5236\uff1f\u53e3\u670d\u300c\u6a59\u76ae\u7d20\u300d\u8207\u6d3b\u5316Cisd2\u57fa\u56e0\u7684\u95dc\u806f\u6027\uff1f\u9664\u4e86Cisd2\u57fa\u56e0\u8207\u8001\u5316\u6709\u95dc\u4ee5\u5916\uff0c\u9084\u6709\u5176\u4ed6\u8207\u8001\u5316\u8abf\u63a7\u76f8\u95dc\u7684\u57fa\u56e0\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

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                          1. \u6c11\u773e\u53ef\u4ee5\u5982\u4f55\u7406\u89e3\u9019\u4efd\u7814\u7a76\uff0c\u5403\u67d1\u6a58\u985e\u6c34\u679c\u771f\u7684\u80fd\u7372\u5f97\u300c\u6a59\u76ae\u7d20\u300d\u55ce\uff1f\u6703\u6709\u52a9\u65bc\u5ef6\u7de9\u8001\u5316\u3001\u5ef6\u9577\u58fd\u547d\u55ce\uff1f<\/strong><\/li>\n<\/ol>\n

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